DNA Adduct Formation in Precision-Cut Rat Liver and Lung Slices Exposed to Benzo[a]pyrene
نویسندگان
چکیده
منابع مشابه
DNA adduct formation in precision-cut rat liver and lung slices exposed to benzo[a]pyrene.
Chemical-DNA adducts provide an integrated measure of exposure, absorption, bioactivation, detoxification, and DNA repair following exposure to a genotoxic agent. Benzo[a]pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon (PAH), can be bioactivated by cytochrome P-450s (CYPs) and epoxide hydrolase to genotoxic metabolites which form covalent adducts with DNA. In this study, we utilize...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2004
ISSN: 1096-0929
DOI: 10.1093/toxsci/kfh030